Updating on the pathogenesis of systemic lupus erythematosus Free sexual chat in mobile phone without login and signed in


11-Jun-2016 11:44

Both physiological and supraphysiological concentrations of oestrogens facilitate humoral responses, leading to increased B cell proliferation and antibody production.

These effects appear to be unique to patients with SLE, indicating that lupus T cells are more sensitive to oestrogens.

In addition, patients with Klinefelter’s syndrome, characterised by hypergonadotrophic hypogonadism, are prone to the development of SLE.

These observations suggest a role for endogenous sex hormones in disease predisposition.

In addition, many polymorphic non-MHC genes have been reported to be associated with SLE.

These include genes that encode mannose binding protein (MBP), tumour necrosis factor α, the T cell receptor, interleukin 6 (IL-6), CR1, immunoglobulin Gm and Km allotypes, FcγRIIA and FcγRIIIA (both Ig G Fc receptors), and heat shock protein 70.

updating on the pathogenesis of systemic lupus erythematosus-63

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Some of these polymorphic genes may confer risk to certain subsets of patients with SLE.

A decrease in complement activity could promote disease susceptibility by impairing the neutralisation and clearance of self and foreign antigens.



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