Updating on the pathogenesis of systemic lupus erythematosus Free sexual chat in mobile phone without login and signed in
Both physiological and supraphysiological concentrations of oestrogens facilitate humoral responses, leading to increased B cell proliferation and antibody production.
These effects appear to be unique to patients with SLE, indicating that lupus T cells are more sensitive to oestrogens.
In addition, patients with Klinefelter’s syndrome, characterised by hypergonadotrophic hypogonadism, are prone to the development of SLE.
These observations suggest a role for endogenous sex hormones in disease predisposition.
In addition, many polymorphic non-MHC genes have been reported to be associated with SLE.
These include genes that encode mannose binding protein (MBP), tumour necrosis factor α, the T cell receptor, interleukin 6 (IL-6), CR1, immunoglobulin Gm and Km allotypes, FcγRIIA and FcγRIIIA (both Ig G Fc receptors), and heat shock protein 70.
Some of these polymorphic genes may confer risk to certain subsets of patients with SLE.
A decrease in complement activity could promote disease susceptibility by impairing the neutralisation and clearance of self and foreign antigens.